autoimmune and inflammatory diseases, including. There is no standard treatment regimen for porokeratosis. ALL RIGHT RESERVED. The Journal of Foot and Ankle Surgery recently reported a meta analysis of outcomes in 1583 Scarf bunionectomies that met their inclusion criteria. There is no known cure for porokeratosis and treatment is generally disappointing. It is more common in females than in males. Instead, your condition may continue to worsen. It is more frequently seen in women, probably because they more readily seek advice for cosmetic concerns. and transmitted securely. When the inflammation is difficult to control, chronic eczema can lead to: Hyperkeratosis. rarediseases.info.nih.gov/diseases/10983/disseminated-superficial-actinic-porokeratosis, jamanetwork.com/journals/jamadermatology/article-abstract/532436, dermnetnz.org/topics/linear-porokeratosis, dermnetnz.org/topics/porokeratosis-of-mibelli, dermnetnz.org/topics/disseminated-superficial-actinic-porokeratosis/, rarediseases.info.nih.gov/diseases/4438/porokeratosis-of-mibelli, rarediseases.info.nih.gov/diseases/8180/punctate-porokeratosis. It consists of a keratinization disorder, which may appear in several clinical forms and can undergo malignant . People with DTD have many health complications related to their. Is usually begins in the childhood and in some instances, the lesions are present at birth. In addition to limiting direct sun exposure, you should always wear sunscreen with an SPF of 30. MNT is the registered trade mark of Healthline Media. If the condition gets worst, a surgery might be needed. (2010). Eczema causes itching, redness and tiny blisters. Some doctors believe porokeratosis are related to foreign bodies that have penetrated into the dermis of the skin causing the skin to produce a protective deposit of skin. Andy. Analogues of D3 vitamin - these are administered as topical treatments as well, being especially recommended for the disseminated superficial actinic porokeratosis. Pictures and symptoms of the red, scaly rash. When it comes to determining the best treatment approach, various factors need to be considered such as the size, location, and nature of the disease. These bumps may slowly spread over the skin and usually do not cause symptoms, though they sometimes cause itching or discomfort while walking. Can diet help improve depression symptoms? These often develop on the torso, arms, or legs. 2022 Nov 6;10(31):11585-11589. doi: 10.12998/wjcc.v10.i31.11585. Porokeratosis Ptychotropica is a highly-infrequent skin condition that is typically observed in middle-aged adults (mean age 47 years). The biopsy should include the raised edge of the lesion. In some cases, porokeratosis may affect one area or appear in multiple places. After treatment, the skin will feel raw and sore. It can be passed on the genes, but it can also affect people with no apparent family history of keratosis. First, I want to let you know that you have the best web site I've found related to foot issues. I received the orthotics Monday afternoon and began wearing them Tuesday. The lesions seen in disseminated superficial actinic porokeratosis begin as pink to brown papules and macules with raised borders in sun-exposed areas and can be asymptomatic or slightly pruritic. Spencer, JM, Katz, BE. Current treatment options in This patch grows in size, and the bumps may become raised with a ring around the outside of each spot. You should also talk to your doctor before trying any home or over-the-counter medications. All rights reserved. Here is a suggestio. The two most common types of this skin condition are porokeratosis of Mibelli and disseminated superficial actinic porokeratosis (DSAP). An All Natural Ointment to Remove Skin Lesions and Growths. In terms of appearance, DSAP is more extensive than other subtypes and appears as reddish and brown spots. Photo Source: www.researchgate.net, Picture 4: Typical signs and symptoms of punctate porokeratotic keratoderma. However, older research suggests that people may inherit PPPD. Food choices that raise your risk of type 2 diabetes, the type of shoe a patient wears, thin soled shoes are worse then cushioned shoes, the amount of walking a person does during the course of a day. appreciate it. Porokeratosis is not contagious, but it may be passed down through genetics. Cryosurgery and photodynamic therapy are also treatment options, although they offered varying results. Thecornoidlamella in porokeratosis is due to an expanding clonal proliferationof unusualkeratinocytes, which is thought to be due genetic mutation[4]. However, a person may undertake treatment to improve the appearance of the affected areas. Do chronic wounds need to be dressed daily? Am J Med Genet. No studies showing the value of prophylactic nonexcisional surgical treatment in reducing the incidence of malignancy within porokeratosis have been reported. 2022 Mar;11(3):1195-1197. doi: 10.4103/jfmpc.jfmpc_1232_21. Would you like email updates of new search results? Debridement can be painful, but often gives immediate relief when done correctly. This site needs JavaScript to work properly. At first, you may notice a small patch of brown bumps. Specialty. Multiple clinical variants of porokeratosis exist. Topical ingenol mebutate gel injures two important . Linear porokeratosis of the foot with dermoscopic manifestations: A case report. Arthrogryposis is a congenital condition present at birth characterized by a stiffening of the joints. Several different treatments have been attempted over the years including injections into the base . The signs and symptoms of Disseminated Superficial Actinic Porokeratosis (DSAP) include: Numerous skin lesions that occur in any part of the body. These lesions may be . It is suggested that cancer may surpass CVD as the number one cause of death in older diabetics. The best course of action is preventing further sun damage. Some types cover large areas of skin (DSP, DSAP, and PPPD) and others are more localized (PM, LP, and PP). Localized hair loss. And this medication is relatively cheap -- as low as $59 for 226 grams (or 8 ounces). Disseminated superficial actinic porokeratosis (DSAP) is a chronic condition characterized by numerous atrophic papules and patches with a distinctive peripheral keratotic ridge, typically found on sun-exposed areas. Porokeratosis Cryotherapy is the most common treatment. Your doctor may suggest monitoring its growth over time. It causes tiny bumps of thickened skin on the soles and palms. (2, 3). In some cases, a biopsy may also be necessary to rule out other conditions or check for cancerous cells. 1974Apr;109(4):5268. Individuals with this condition often develop other . Your doctor will monitor the spots and may take a sample of skin to biopsy if the spots change too much. 3200 Downwood Circle, NW Suite 210. Hello how are you, I would like to find out if there is a natural treatment for porokeratosis? Any suggestions would be appreciated. We performed a systematic literature search in an electronic database for published literature. Facial porokeratosis: A series of six patients. 2006Sep;45(9):10779. The diagnosis of porokeratosis typically involves a physical examination. Please note that we use cookies necessary for the functioning of our website, cookies that optimize the performance. She has had a succession of podiatrists call it . The condition occurs most often in light-skinned adults in their thirties or forties and appears in at least 6 distinct sub-types. "Successful treatment of porokeratosis of Mibelli with diamond fraise dermabrasion". In cases where there is pain during ambulation most podiatrists will attempt to curette (carve out) the lesion(s) from the surrounding skin. 3,4 Successful treatment of DSAP often is difficult . The recommendation is to use cholesterol/lovastin morning and night for 2 months, but for up to 3 months as may be needed. Healthline Media does not provide medical advice, diagnosis, or treatment. Sertznig P, et al. A distinctiveclinical variant of porokeratosis of Mibelli. Punctate porokeratosis is a very rare subtype of porokeratosis. 1996;192(3):255-8. doi: 10.1159/000246378. 1-4 Oral acitretin has proven effective in widespread disease, but recurrence following discontinuation is . expected, by itself, to be definitive treatment; or CPT 17000 (CPT 17003, CPT 17004) - destruction (eg, laser surgery, electrosurgery, cryosurgery, chemosurgery, surgical curettement), benign lesion . A 2017 review of treatment for porokeratosis lists the following options: The exact causes of certain subtypes of porokeratosis are unknown. People describe the discomfort as if there were several pebbles stuck to the bottom of their foot or in their shoe. Because of supply chain shortages as well as staffing shortages particularly during the pandemic, many institutions extended the time between dressing changes for chronic wounds. People that met me thought that is was a communicable disease. Punctate porokeratosis palmaris et plantaris. It appears in the late childhood to early adulthood. 8600 Rockville Pike Arch Dermatol. Some DSAP cases have been reported in patients with acute immune compromised situations, particularly in the elderly. Conclusion: Your doctor may prescribe Imiquimod cream, 5-fluorouracil cream, or retinoid cream because they are shown to improve skin affected by porokeratosis.. Intractable plantar keratosis (IPK) is a focused, painful lesion that commonly takes the form of a discrete, focused callus, usually about 1 cm, on the plantar aspect of the forefoot. A person with porokeratosis should consider seeing a doctor or dermatologist. Leave on as long as possible or overnight. Although it usually manifests during adolescence or a persons early 20s, there have been cases of older individuals developing PPPD. After the keratin and debris are out the spots will heal rather quickly by using an acne medication, 2% salicylic acid (over-the-counter). Porokeratosis of gluteal region: A case report. All Rights Reserved. In some types of porokeratosis, a family history is present, consistent with a genetic predisposition [3]. DSAP is considered a pre-cancerous skin growth, although it rarely turns into cancer. Does glucosamine or MSM reduce arthritis pain? Porokeratosis of Mibelli of the axillae: treatment with topical imiquimod. Surgical approach is intended for malignant form of porokeratosis. Other forms of treatment for porokeratosis plantaris include the use of keratolytic agents such as salicylic acid whose goal is "eat" away at the lesion by macerating the area. The name porokeratosis means scaly pore, and is a misnomer as porokeratosis is not related to pores. Most patients with AKs need 2 PDT treatments, with the second treatment given 3 weeks after the first. Pediatrics. 1,2 Treatment of DSAP is warranted not only for cosmetic and symptomatic benefits but also to prevent malignant transformation. 2003 Nov;44(4):281-3. doi: 10.1046/j.1440-0960.2003.00010.x. Types of natural remedies for actinic keratosis. F: 404-350-5640. [email protected]. Included is detail on types of hyperkeratosis and when to see a, Actinic keratosis is a precancerous skin condition that causes patches of rough, patchy lesions. Several different treatments have been attempted over the years including injections into the base of the lesions with dehydrogenated alcohol, debridements, and exfoliating agents. Porokeratosis is an uncommon diagnosis. Porokeratosis of Mibelli. The Global Porokeratosis Treatment market is anticipated to rise at a considerable rate during the forecast period, between 2023 and 2028. The Mental Toll of Disseminated Superficial Actinic Porokeratosis. Hence, it is believed that anyone can get porokeratosis regardless if you have the family history or not. There is a high possibility of developing skin cancer. LP and PPPD begin on palms and soles but can spread elsewhere. Here is what the various D3 isomers look like, including tacalcitol:http://www.uspharmacist.com/CMSImagesContent/2009/7/USP0907-Consult-F2.gif. Last medically reviewed on January 13, 2021, A look at hyperkeratosis, a condition where the skin becomes thicker than normal. (2012). Thanks for a most interesting website, which has helped a lot. Tacalcitol is marketed under several names, including Curatoderm and Bonalfa. Pavilion Compounding Pharmacy is located in Atlanta, GA within the Buckhead area. If you have a porokeratosis, you are strongly advised to visit your doctor regularly to watch for any signs of skin cancer or worsening of the condition. 2017 Aug;18(4):435-449. doi: 10.1007/s40257-017-0271-3. The two most common types, PM and DSAP, tend to be on your arms and legs. Please enable it to take advantage of the complete set of features! The only solution that works well is to completely clean out the spots. Currently, there is no cure for porokeratosis. [8488][8489] DSAP usually starts during the third or fourth decade of life and rarely affects children. Disseminated superficial actinic porokeratosis (DSAP) is a skin condition that causes dry, scaly patches. Because of a lack of treatment standards for PK, European and international guidelines cannot be created. The increased occurrence of disseminated superficial actinic . Cover affected areas of skin when you are in the sun and wear strong sunscreens. Would like to know what other people have used with success. Here are some of the key characteristics: The exact cause of porokeratosis isnt known, and some study results have been contradictory. There are many options for the treatment of disseminated superficial actinic porokeratosis. You should also wear UV-protectant clothing, a wide-brimmed hat, and sunglasses for added protection. Small Mosaic Wart Laser Removal Treatments, Most Effective Laser Nail Fungus Treatment, Understanding Lasers and Laser Treatments, Laser Spider Vein Removal Treatment Packages, Laser Scar Reduction and Skin Rejuvenation. Linear porokeratosis is similar in appearance to DSP and DSAP, but it has the distinguishing feature of appearing along Blaschko lines. Craniosynostosis is a birth defect that can cause problems with a baby's head shape and later cognitive ability. Disseminated superficial actinic porokeratosis (DSAP) is a non-contagious skin condition with apparent genetic origin in the SART3 gene. A person should also consider consulting their doctor if they experience any pain, itching, discoloration, or bleeding around the affected sites. Simultaneous co-occurrence of porokeratosis of mibelli with disseminated superficial actinic porokeratosis. Porokeratosis typically doesn't require treatment. Annular pancreas is an extra ring of pancreatic tissue surrounding the small intestine. DSAP A review. Porokeratosis is the general term for a group of skin conditions causing small, discolored bumps with a raised border to appear on the skin. (2009). Factors that may exacerbate the pain include: For this reason there are various treatments ranging from absolutely nothing to surgical excision. Each porokeratosis lesion has a characteristic ridge on its border and a central furrow. PMC These tend to appear symmetrically across a persons back, arms, legs, and shoulders. the amount of, or lack of fat on the bottom of the foot. It is a must to protect the skin from extreme heat of the sun so as to prevent the possibility of having skin cancer. Regards, I thank you for putting together this incredible website. We hypothesized that topical therapy that aims to replenish cholesterol, an essential mevalonate pathway end-product, and block the accumulation of mevalonate pathway toxic metabolites could alleviate porokeratosis. DSAP is caused by an ultra-sensitivity to sunlight. Porokeratosis can be present at birth or not develop until adult life [2], depending on the type of porokeratosis. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. (n.d.). The site is secure. Porokeratosis plaques can become malignant, so this skin health issue should be addressed properly. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527053/, https://escholarship.org/uc/item/5n1901d5, https://www.bad.org.uk/patient-information-leaflets/disseminated-superficial-actinic-porokeratosis/?showmore=1&returnlink=https%3A%2F%2Fwww.bad.org.uk%2Fpatient-information-leaflets#.X_Cb0Kr7TeR, https://www.spandidos-publications.com/10.3892/etm.2014.1803, https://escholarship.org/uc/item/5j96k8qd, https://www.ncbi.nlm.nih.gov/books/NBK459202/, https://www1.racgp.org.au/ajgp/2019/november/precancerous-skin-lesion-often-misdiagnosed, https://rarediseases.info.nih.gov/diseases/4438/porokeratosis-of-mibelli/cases/36175, https://rarediseases.info.nih.gov/diseases/8180/punctate-porokeratosis, https://clinmedjournals.org/articles/ijdrt/journal-of-dermatology-research-and-therapy-ijdrt-5-063.pdf, https://www.researchgate.net/profile/Arfan_Bari/publication/288775438_Porokeratosis_A_review_of_unique_group_of_keratinizing_disorder/links/5ee98151299bf1faac5c7c34/Porokeratosis-A-review-of-unique-group-of-keratinizing-disorder.pdf, https://www.sciencedirect.com/science/article/pii/S1578219020302055, https://pubmed.ncbi.nlm.nih.gov/28283894/, https://dermnetnz.org/topics/porokeratosis/, https://www.ncbi.nlm.nih.gov/books/NBK532290/. After two days I would say that I have noticed a huge improvement in the discomfort I have been experiencing. DermNet does not provide an online consultation service. They often have raised rings around the spots. 1187-8. Earth Clinic can help you find Natural Remedies for Porokeratosis, a clonal disorder of keratinization characterized by one or more atrophic patches. Unfortunately, I use my fingernails for lack of a better method. It is sometimes confused with actinic keratosis which is also caused by sun exposure (See Patient Information Leaflet on Actinic Keratoses ); however, actinic keratosis is . 1992. pp. Because of their description many patients will refer to them as seed corns. Rouhani P, et al. DSAP is more common on your arms and legs but may also affect skin that is damaged from the sun. If you notice any change in color or size, see your doctor. [1] : 533 It most often presents in sun-exposed areas of the body. Apply virgin coconut oil once a day. Take a reasonably sized eggplant and mince it well. These lesions are described as dozens of discrete or grouped seed-like hyperkeratotic lesions with characteristic thin, raised ridge-like margins that develop on the palms and the soles. This type of porokeratosis develops on your skin, and may also affect other tissue in your body. 2006;17(5):319-20. doi: 10.1080/09546630600944116. Remove duct tape and re-evaluate, if you still feel pain or discomfort wait 48 hours and repeat. Prune belly syndrome is a rare congenital condition that affects the abdominal muscles, the abdomen's appearance, and other systems in the body. To learn more about our cookies, how we use them and their benefits, please read our Privacy Policy, Posted by Mexicogirl (Chapala, Jalisco, Mexico) on 10/25/2010, Posted by Veronica (Missouri) on 02/25/2017, Posted by Bandy12 (San Antonio, Tx) on 08/10/2011. World J Clin Cases. Overview of Diastrophic Dysplasia, a Genetic Condition Affecting the Cartilage, What to Know If Your Child Is Diagnosed with Arthrogryposis, What You Need to Know About Prune Belly Syndrome, disseminated superficial porokeratosis (DSP), disseminated superficial actinic porokeratosis (DSAP), porokeratosis palmaris et plantaris disseminata (PPPD), also known as porokeratosis of Mantoux. However, some people develop small hard growths usually more than one on the bottom of their feet, many will complain they feel like they have a stone in their shoe. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. If you have any concerns with your skin or its treatment, see a dermatologist for advice. Sunlight, UV rays, and other radiation worsen the condition. (2013)/ Unilateral punctate porokeratosis: Case report. Apple cider vinegar has been considered as an effective remedy that can help treat a number of health problems. Although the condition is usually benign, a small number of people may develop skin cancer within a lesion. Sasson M, Krain AD. Surgical interventions and cryotherapy may be preferred in areas where the use of topical agents is difficult or contraindicated. DSAP is a skin condition with multiple, dry, scaly rings, each measuring up to 1 cm (1/2 inch) across. Contact us at Clark Podiatry Center at www.clarkpodiatry.com for more information or call for an appointment at 732-382-3470 to have them removed--painlessly and without needles! Porokeratosis is a rare, acquired or inherited disorder of keratinization characterized by one or more atrophic macules or patches, each surrounded by a distinctive hyperkeratotic, ridge-like border called a "cornoid lamella" ( picture 1A-B) [ 1,2 ]. A good review of the possible benefits to taking glucosamine, chondroitin or MSM for arthritis. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Smoking Pot Every Day Linked to Heart Risks, Artificial Sweetener Linked to Heart Risks, FDA Authorizes First At-Home Test for COVID and Flu, New Book: Take Control of Your Heart Disease Risk, MINOCA: The Heart Attack You Didnt See Coming, Health News and Information, Delivered to Your Inbox. 2009 Jan-Feb;19(1):25-8. doi: 10.1684/ejd.2008.0567. Important Disclaimer: The information contained on Healthy Focus is intended for informational and educational purposes only. An ideal form of treatment for this benign chronic condition should be pain free, effective, safe, and nonscarring. An ointment mill in use to provide reduced particle sizes and a smooth, elegant formulation for a unique compounding treatment for porokeratosis. The most common therapies associated with development of porokeratosis is biologic use, phototherapy, and radiotherapy. Similar to porokeratosis of Mibelli, this condition appears as patches of brown, scaly spots. Image Source: escholarship.org. When going out in the sun, make sure you wear sunscreen or wear long sleeves. Cardiovascular health: Insomnia linked to greater risk of heart attack. Background: Porokeratosis of Mibelli showed the best outcomes after treatment with imiquimod cream and linear PK responded well to topical or systemic retinoids. All rights reserved. Disseminated superficial actinic porokeratosis (DSAP). I have mostly the red irritated spots that contain lumps of keratin--some are linear and some are round with raised edges; those raised edges also contain keratin. Explain the natural course of the lesions and that most of them can be relatively difficult to treat. Porokeratosis can become very painful over time depending on the location. First, I'd like to thank you for all the information that you provide on your website and the opportunity to write to you. Porokeratosis are not associated with any particular type bony prominence, structure in the foot, or virus. By this time, a patient seeking treatment for a "porokeratosis" or "IPK" is frustrated and is "doctor shopping." Her history and physical exam show that she has had the 2 mm diameter lesion for six months. A total of 88 articles fulfilling our inclusion criteria were found. It doesnt appear until sun damage occurs, so it is also more prevalent in people with fair skin. Prevention is the only treatment that can provide best relief. Authors Till Weidner 1 . 10 Many of the traditional therapies used for PM had previously been used in our patient, . vol. There are treatment options to help. Porokeratosis: Present concepts. Did you make your own lavender oil? Cureus. We avoid using tertiary references. Make an Appointment. These lesions are thought to be nothing more than plugged sweat glands however there is some debate as to whether this is true or not. Thepathologyof porokeratosisis very distinct, but it may be necessary to point out the clinical features for the pathologist to find a cornoid lamella within the pathological specimen. Eczema is also called dermatitis. Porokeratosis refers to a group of skin conditions that typically appear as small patches with a raised edge. (2010). It usually affects the limbs, especially the hands and feet. Learn about causes, possible symptoms, complications, and more. A few types of meds can treat blocked sweat glands. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). As PPPD is an extremely rare subtype of porokeratosis, there is a lack of research exploring its causes and potential triggers. Review. Looking up one of the Searches yields this one:www.ncbi.nlm.nih.gov/pubmed/10071323. However, people may also have an inherent genetic risk of developing this type of porokeratosis. Photodynamic therapy, however, has shown some success in treatment. Disseminated superficial actinic porokeratosis. Certain food groups have a tendency to raise your blood sugars and should be avoided. If you have the condition, you may pass a predisposition for it down to your children. Perrin's Blend is a simple, all natural, antioxidant, grape seed extract ointment for Actinic Keratosis and other skin growths. , Porokeratosis of Mibelli. Actinic keratoses can be removed by freezing them with liquid nitrogen. However, theories as to what causes porokeratosis include: A person with porokeratosis should consider limiting their sun exposure and regularly moisturizing the affected areas. We're putting our Laser Center in the spotlight this month and offering 20% off all laser packages, except for the powerhouse CO2 laser, which is 15% off. A systematic review of light and laser treatment modalities was conducted to include 26 cases of patients with DSAP. (4, 5). Surgical treatment is essential for porokeratosis lesions that have undergone malignant transformation. 2019 Health Fixit. What you can do to improve your condition? Posted by Andy (Brooklyn, NY) on 03/03/2021. The pathology of porokeratosis is very distinct, but it may be necessary to point out the clinical features for the pathologist to find a cornoid lamella within the pathological specimen. Disseminated Superficial Actinic Porokeratosis (DSAP): A Case Report Highlighting the Clinical, Dermatoscopic, and Pathology Features of the Condition. Scraping (curettage) or shaving the skin's surface. Foods that are known to have immune boosting, anti-cancer properties are garlic, cabbage, tomatoes, onion, olive oil, grapes, white fish, cabbage, hot peppers, and green tea. Patients usually have other forms of porokeratosis as well, most commonly the linear or Mibelli types. $53.99 1 oz. to thank you for an EXCELLENT website. (8). Bethesda, MD 20894, Web Policies It takes only a few minutes and can be done in . Topical vitamin D acid derivatives may be the best therapeutic option for disseminated PK. Earth Clinic can help you find Natural Remedies for Porokeratosis, a clonal disorder of keratinization characterized by one or more atrophic patches. Disseminated superficial actinic porokeratosis (DSAP) is a very common form of porokeratosis. What is the latest research on the form of cancer Jimmy Carter has? Gu C-Y, et al. The spots covered entirely my legs and arms, such that . DOI: Lanka P, et al. There is a 3% risk that a person with DSAP will develop skin cancer. Systematic review resulted in 14 articles to be included . Freezing a growth with liquid nitrogen (cryotherapy) can be an effective way to remove a seborrheic keratosis. No ideal treatment of disseminated superficial actinic porokeratosis has been found. It works by removing the surface layer of the skin. Ramakrishnan R, Vignesh TA, Durai PCT, Narasimhan M. J Family Med Prim Care. The patient says it has increased in size since it was debrided by another DPM. (This might involve "off-label use", which is allowed! Keep in mind that while porokeratosis of Mibelli may appear on several parts of your body, it doesnt spread via contact. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. The incidence is higher in women than men. Treatment of porokeratosis. Dermatology. official website and that any information you provide is encrypted
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